Quantification and optimisation of lung ventilation SPECT images
نویسنده
چکیده
................................................................................................................... 1 SAMMANFATTNING ................................................................................................... 3 LIST OF PAPERS ........................................................................................................... 5 ABBREVIATIONS ......................................................................................................... 7 INTRODUCTION ........................................................................................................... 9 AIM OF THE THESIS .................................................................................................. 11 BACKGROUND ........................................................................................................... 13 The human lung ...................................................................................................... 13 Lung diseases .......................................................................................................... 14 Diagnostic tests of lung function ............................................................................ 16 Lung function tests ............................................................................................ 16 High resolution computed tomography, HRCT ................................................ 17 Planar scintigraphy .......................................................................................... 17 Single photon emission computed tomography, SPECT .................................. 17 Radiotracers for lung SPECT ................................................................................. 18 The gamma camera ................................................................................................. 19 Physical effects ................................................................................................. 20 Acquisition parameters ..................................................................................... 22 Monte Carlo simulations and phantoms ................................................................. 22 Reconstruction techniques ...................................................................................... 24 Filtered back projection, FBP .......................................................................... 24 Ordered subset expectation maximisation, OSEM ........................................... 24 Noise reduction ................................................................................................. 25 Reconstruction parameters............................................................................... 25 The resulting image ................................................................................................ 26 Phantom images ............................................................................................... 26 Human images .................................................................................................. 26 Optimisation ........................................................................................................... 27 IMAGE AND COMPUTER PROCESSING ................................................................ 29
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